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Chemistry
Cetyl myristoleate, an oil, is the hexadecyl ester of the unsaturated
fatty acid cis-9-tetradecenoic acid. The common name for the
acid is myristoleic acid. Myristoleic acid is found commonly
in fish oils, whale oils, dairy butter, and kombo butter. The
chemical formula for cetyl myristoleate is (Z)-ROCO(CH2)7CH=CH(CH2)3CH3.
Cetyl myristoleate was unrecorded in chemical literature until
Diehl's discovery was reported. The current Merck Index of Chemicals
does not list cetyl myristoleate. A search of Chemical Abstracts
lists Diehl's method of extracting cetyl myristoleate from mice
but contains no reference to cetyl myristoleate prior to his
1977 patent.
Experimentation
To test his theory that mice are immune to arthritis because
of cetyl myristoleate, Diehl began to experiment on laboratory
rats. This research was reported in an article written in conjunction
with one of his colleagues at NIH in the Journal of Pharmaceutical
Sciences.6
In summary, this paper reports that ten normal mice were
injected in the tail with Freund's adjutant (heat-killed desiccated
Mycobacterium butyricum) to which rats and certain other rodents
are susceptible. In a period of 10-20 days, no noticeable swelling
developed in the legs or paws. Mice in a second group were injected
in the left hind paw. Again, after 10-20 days, no swelling was
detected as determined by comparison of the measurements of paws
at the time of injection.
Then, a group of rats was injected with cetyl myristoleate, and
48 hours later, they were given the arthritis-inducing Freund's
adjutant. A control group of rats was given Freund's adjutant
only. Both groups of rats were observed for a total of 58 days
with respect to weight change, hind and front leg swelling, and
general well-being. All rats receiving only Freund's adjutant
developed severe swelling of the front and hind legs, lagged
in weight gain, and were lethargic and morbid. Those receiving
cetyl myristoleate before receiving Freund's adjutant grew an
average of 5.7 times as much as the control group and had little
if any evidence of swelling or other symptoms of polyarthritis.
The authors concluded that it was apparent that cetyl myristoleate
gave virtually complete protection against adjutant-induced arthritis
in rats. Furthermore, a 1:1 mixture of cetyl myristoleate and
a homologue, cetyl oleate, gave results not significantly different
from administering cetyl myristoleate alone.
A Hiatus
Diehl patented his discovery in 1977, receiving a use patent
for rheumatoid arthritis. He then sought pharmaceutical companies
to conduct human trials with cetyl myristoleate, but none were
interested in his discovery. Perhaps the lack of interest was
because cetyl myristoleate was a natural substance and could
not be granted a product patent, or maybe because drug companies
know they will have to run through 25,000 to 35,000 substances
before they find one that makes it to market. Diehl had made
a major nutritional discovery, and no one was interested! Being
a scientist, not a marketing expert, Diehl let his discovery
lay dormant for about 15 years.
Cetyl Myristoleate
Cures
Diehl's Arthritis
As Diehl got older, he began to experience some osteoarthritis
in his hands, his knees, and his heels. His family physician
tried the usual regimen of cortisone and non-steroidal anti-inflammatory
drugs without much effect on the course of the disease. Finally
his physician told Harry he could not have any more cortisone.
"So," Diehl said, "I thought about my discovery,
and I decided to make a batch and use it on myself." He
did, and successfully cured himself of his osteoarthritis.
Many of his family members and friends became aware of the relief
Diehl got from his discovery, and they wanted to try it too.
Time after time, people with both rheumatoid and osteoarthritis
received astounding relief with cetyl myristoleate. Before long,
family members and friends grew into customers, and cetyl myristoleate
appeared on the market as a dietary supplement in 1991.
Clinical Observations
and Usage
In common with many other natural substances and drugs, the exact
mechanism of cetyl myristoleate's physiologic activity is unclear.
As a fatty acid ester, it appears to have the same characteristics
as the essential fatty acids, linoleic and alpha linolenic acids,
except stronger and longer lasting. These fatty acids are referred
to as "essential fatty acids" because the human body
cannot make them and we must ingest them in our diets. These
EFA's truly are essential to normal cell structure and body function
and function as components of nerve cells, cell membranes, and
hormone-like substances known as prostaglandins. Many of the
beneficial effects of a diet rich in plant foods is a result
of the low levels of saturated fat and the relatively higher
levels of EFA's. While a diet high in saturated fat has been
linked to many chronic diseases, a diet low in saturated fat
but high in EFA's prevents these very same diseases.7
The use of EFA's over an extended period of time has been shown
to decrease the pain, inflammation, and limitation of motion
of arthritis.8
The difference between the activity of EFA's and cetyl myristoleate
is that the quantity required and the period of time over which
EFA's are taken are markedly longer. Cetyl myristoleate is taken
in a one month course of about 13 grams, while EFA's must be
taken over extended periods, sometimes many years, and intake
varies widely from hundreds to thousands of grams. Cetyl myristoleate
seems to have properties in common with EFA's, but it acts faster
and lasts longer.
Because EFA's are necessary for normal functioning of all tissue,
it is not surprising that the list of symptoms of EFA deficiency
is a long one. In chronic inflammatory processes, the supply
of EFA's is depleted. Cetyl myristoleate appears to have the
ability to correct the imbalance created by chronic inflammation.
Like E
Venous blood from the gastrointestinal tract is carried to the
liver via the portal vein. With the exception of intestinal chylomicrons
that enter the lymphatics, all absorbed products pass initially
through the liver, and in most instances are extracted or modified
before passage into systemic circulation.9
Since all fatty acids enter systemic circulation through the
liver, an oil like cetyl myristoleate would begin its systemic
circulation from the liver also. It is speculated that cetyl
myristoleate stimulates the production of immunoglobulins and
series 1 and 3 prostaglandins, which could be one explanation
for why cetyl myristoleate has such potent effect in auto-immune
and inflammatory conditions.
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CMO
or Cetyl Myristoleate for Arthritis Pain and Arthritic Conditions.
Ultimate CM Plus
Ultimate
CM Plus
is the newest addition to the growing family of Youngevity's
Tablets and Caps.
Ultimate
CM Plus
main ingredient is CM Complex. This break through compound which
includes Cetyl Myristoleate has been medically and scientifically
demonstrated to promote the relief of joint and related discomfort.
Make CM Plus part of your daily program.
|
Supplement Facts |
|
Each
Capsule Contains: |
| |
Amount |
%RDI |
| Methyl Sultonylmethane |
150 mg |
** |
| CM Complex |
1050 mg |
** |
| Cetyl Myristoleate |
1 |
** |
| Cetyl Myristate |
1 |
** |
| Cetyl Palmitoleate |
1 |
** |
| Cetyl Palmitate |
1 |
** |
| Cetyl Laurate |
1 |
** |
| Cetyl Oleate |
1 |
** |
|
** RDI's have not
been established |
|
Item # 20985
- 90 capsules per bottle
 Wholesale Price: $46.00
Ultimate Cm Plus Case (4
Bottles) Wholesale $178.00
|
