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Chemistry
Cetyl myristoleate, an
oil, is the hexadecyl ester of the unsaturated fatty acid cis-9-tetradecenoic
acid. The common name for the acid is myristoleic acid. Myristoleic
acid is found commonly in fish oils, whale oils, dairy butter,
and kombo butter. The chemical formula for cetyl myristoleate
is (Z)-ROCO(CH2)7CH=CH(CH2)3CH3. Cetyl myristoleate was unrecorded
in chemical literature until Diehl's discovery was reported.
The current Merck Index of Chemicals does not list cetyl myristoleate.
A search of Chemical Abstracts lists Diehl's method of extracting
cetyl myristoleate from mice but contains no reference to cetyl
myristoleate prior to his 1977 patent.
Experimentation
To test his theory that
mice are immune to arthritis because of cetyl myristoleate, Diehl
began to experiment on laboratory rats. This research was reported
in an article written in conjunction with one of his colleagues
at NIH in the Journal of Pharmaceutical Sciences.6
In summary, this paper reports that ten normal mice were
injected in the tail with Freund's Adjuvant (heat-killed desiccated
Mycobacterium butyricum) to which rats and certain other rodents
are susceptible. In a period of 10-20 days, no noticeable swelling
developed in the legs or paws. Mice in a second group were injected
in the left hind paw. Again, after 10-20 days, no swelling was
detected as determined by comparison of the measurements of paws
at the time of injection.
Then, a group of rats was injected with cetyl myristoleate,
and 48 hours later, they were given the arthritis-inducing Freund's
adjuvant. A control group of rats was given Freund's adjuvant
only. Both groups of rats were observed for a total of 58 days
with respect to weight change, hind and front leg swelling, and
general well-being. All rats receiving only Freund's adjuvant
developed severe swelling of the front and hind legs, lagged
in weight gain, and were lethargic and morbid. Those receiving
cetyl myristoleate before receiving Freund's adjuvant grew an
average of 5.7 times as much as the control group and had little
if any evidence of swelling or other symptoms of polyarthritis.
The authors concluded that it
was apparent that cetyl myristoleate gave virtually complete
protection against adjuvant-induced arthritis in rats. Furthermore,
a 1:1 mixture of cetyl myristoleate and a homologue, cetyl oleate,
gave results not significantly different from administering cetyl
myristoleate alone.
A Hiatus
Diehl patented his discovery
in 1977, receiving a use patent for rheumatoid arthritis. He
then sought pharmaceutical companies to conduct human trials
with cetyl myristoleate, but none were interested in his discovery.
Perhaps the lack of interest was because cetyl myristoleate was
a natural substance and could not be granted a product patent,
or maybe because drug companies know they will have to run through
25,000 to 35,000 substances before they find one that makes it
to market. Diehl had made a major nutritional discovery, and
no one was interested! Being a scientist, not a marketing expert,
Diehl let his discovery lay dormant for about 15 years.
Diehl's Arthritis
As Diehl got older, he
began to experience some osteoarthritis in his hands, his knees,
and his heels. His family physician tried the usual regimen of
cortisone and non-steroidal anti-inflammatory drugs without much
effect on the course of the disease. Finally his physician told
Harry he could not have any more cortisone. "So," Diehl
said, "I thought about my discovery, and I decided to make
a batch and use it on myself." He did, and successfully
cured himself of his osteoarthritis.
Many of his family members and
friends became aware of the relief Diehl got from his discovery,
and they wanted to try it too. Time after time, people with both
rheumatoid and osteoarthritis received astounding relief with
cetyl myristoleate. Before long, family members and friends grew
into customers, and cetyl myristoleate appeared on the market
as a dietary supplement in 1991.
Clinical Observations and
Usage
In common with many other
natural substances and drugs, the exact mechanism of cetyl myristoleate's
physiologic activity is unclear. As a fatty acid ester, it appears
to have the same characteristics as the essential fatty acids,
linoleic and alpha linolenic acids, except stronger and longer
lasting. These fatty acids are referred to as "essential
fatty acids" because the human body cannot make them and
we must ingest them in our diets. These EFA's truly are essential
to normal cell structure and body function and function as components
of nerve cells, cell membranes, and hormone-like substances known
as prostaglandins. Many of the beneficial effects of a diet rich
in plant foods is a result of the low levels of saturated fat
and the relatively higher levels of EFA's. While a diet high
in saturated fat has been linked to many chronic diseases, a
diet low in saturated fat but high in EFA's prevents these very
same diseases. The use of EFA's over an extended period of time
has been shown to decrease the pain, inflammation, and limitation
of motion of arthritis.
The difference between the activity of EFA's and cetyl myristoleate
is that the quantity required and the period of time over which
EFA's are taken are markedly longer. Cetyl myristoleate is taken
in a one month course of about 13 grams, while EFA's must be
taken over extended periods, sometimes many years, and intake
varies widely from hundreds to thousands of grams. Cetyl myristoleate
seems to have properties in common with EFA's, but it acts faster
and lasts longer.
Because EFA's are necessary for
normal functioning of all tissue, it is not surprising that the
list of symptoms of EFA deficiency is a long one. In chronic
inflammatory processes, the supply of EFA's is depleted. Cetyl
myristoleate appears to have the ability to correct the imbalance
created by chronic inflammation. Like E
Venous blood from the gastrointestinal
tract is carried to the liver via the portal vein. With the exception
of intestinal chylomicrons that enter the lymphatics, all absorbed
products pass initially through the liver, and in most instances
are extracted or modified before passage into systemic circulation.
Since all fatty acids enter systemic circulation through the
liver, an oil like cetyl myristoleate would begin its systemic
circulation from the liver also. It is speculated that cetyl
myristoleate stimulates the production of immunoglobulins and
series 1 and 3 prostaglandins, which could be one explanation
for why cetyl myristoleate has such potent effect in auto-immune
and inflammatory conditions.
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CMO
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The revolutionary compound found in UltimateCM
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which is a proprietary blend of Cetyl Myristoleate synergistically
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- Modulates the
immune system function
- Helps repair
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- Continuously
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- Increases the
level of the collagen in the skin yielding elasticity and better
skin tone
- Increases suppleness
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Cetyl Myristoleate News.
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|
Supplement Facts |
|
3 Capsules Contains: |
| |
Amount |
%RDI |
| Methyl Sultonylmethane |
150 mg |
** |
| CM Complex |
1050 mg |
** |
| Cetyl Myristoleate |
a |
** |
| Cetyl Myristate |
a |
** |
| Cetyl Palmitoleate |
a |
** |
| Cetyl Palmitate |
a |
** |
| Cetyl Laurate |
a |
** |
| Cetyl Oleate |
a |
** |
|
** RDI's have not been
established |
|
UltimateCM Plus # 20985 - 90 capsules per bottle - Wholesale price:
$46.00
Celadrin
|
